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A Catalyst for Efficient and Highly Enantioselective Hydrogenation of Aromatic, Heteroaromatic, and α,β-Unsaturated Ketones

Mark J. Burk, William Hems, Daniela Herzberg, Christophe Malan and Antonio Zanotti-Gerosa*

*Chirotech Technology Limited, Ascot Fine Chemicals, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K., Email:

M. J. Burk, W. Hems, D. Herzberg, C. Malan, A. Zanotti-Gerosa, Org. Lett., 2000, 2, 4173-4176.

DOI: 10.1021/ol000309n

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PhanePhos-ruthenium-diamine complexes efficiently catalyze an asymmetric hydrogenation of a wide range of aromatic, heteroaromatic, and α,β-unsaturated ketones with excellent enantioselectivity.

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Key Words

reduction of carbonyl compounds, hydrogen

ID: J54-Y2000