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Synthesis of 2,3-Dihydroisoxazoles from Propargylic N-Hydroxylamines via Zn(II)-Catalyzed Ring-Closure Reaction

Patrick Aschwanden, Doug E. Frantz and Erick M. Carreira

*Laboratorium für Organische Chemie, ETH Zürich, HCI H335, Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland, Email:

P. Aschwanden, D. E. Frantz, E. M. Carreira, Org. Lett., 2000, 2, 2331-2333.

DOI: 10.1021/ol006095r


The combination of ZnI2 and DMAP catalyzes a mild cyclization reaction of propargylic N-hydroxylamines to 2,3,5-trisubstituted 2,3-dihydroisoxazoles.

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ID: J54-Y2000