Organic Chemistry Portal



Strong Bicyclic Guanidine Base-Promoted Wittig and Horner-Wadsworth-Emmons Reactions

Daniele Simoni*, Marcello Rossi, Riccardo Rondanin, Angelica Mazzali, Riccardo Baruchello, Cinzia Malagutti, Marinella Roberti and Francesco Paolo Invidiata

*Dipartimento di Scienze Farmaceutiche, UniversitÓ di Ferrara, Via Fossato di Mortara 17−19, 44100 Ferrara, Italy, Email:

D. Simoni, M. Rossi, R. Rondanin, A. Mazzali, R. Baruchello, C. Malagutti, M. Roberti, F. P. Ividiata, Org. Lett., 2000, 2, 3765-3768.

DOI: 10.1021/ol0001665 (free Supporting Information)

see article for more reactions


The guanidine bases TBD and MTBD promote convenient Wittig and Horner-Wadsworth-Emmons reactions under mild reaction conditions with high efficiency and facile isolation of the final products.

see article for more examples

Key Words

Wittig reaction

ID: J54-Y2000