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A New Condensation Reaction for the Synthesis of Carboxylic Esters from Nearly Equimolar Amounts of Carboxylic Acids and Alcohols Using 2-Methyl-6-nitrobenzoic Anhydride

Isamu Shiina, Ryoutarou Ibuka, Mari Kubota

*Department of Applied Chemistry, Faculty of Science, Tokyo University of ScienceKagurazaka, Shinjuku-ku, Tokyo, Email:

I. Shiina, R. Ibuka, M. Kubota, Chem. Lett., 2002, 286-287.

DOI: 10.1246/cl.2002.286

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The combination of 2-methyl-6-nitrobenzoic anhydride with triethylamine in the presence of a catalytic amount of 4-(dimethylamino)pyridine enables the synthesis of various carboxylic esters in excellent yields with high chemoselectivities from nearly equimolar amounts of carboxylic acids and alcohols.

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Key Words

Yamaguchi esterification

ID: JXX-Y2002