Regioselective Chlorothiolation of Alkenes with Sulfonyl Chlorides
Jingjing Wei, Shuaishuai Liang, Lvqi Jiang*, Yasir Mumtaz and Wen-bin Yi*
*School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, P. R. China, Email: lvqi.jiangnjust.edu.cn, yiwbnjust.edu.cn
J. Wei, S. Liang, L. Jiang, Y. Mumtaz, Y.-b. Yi, J. Org. Chem., 2020, 85, 977-984.
DOI: 10.1021/acs.joc.9b02920 (free Supporting Information)
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A highly regioselective chlorothiolation of alkenes with sulfonyl chlorides is compatible with a variety of functional groups and can be scaled up to the gram scale. The employment of readily available reactants and mild reaction conditions makes this process very practical.
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