Selective Acylation of Aryl- and Heteroarylmagnesium Reagents with Esters in Continuous Flow
Benjamin Heinz, Dimitrije Djukanovic, Maximilian A. Ganiek, Benjamin Martin, Berthold Schenkel and Paul Knochel*
*Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377 Munich, Germany,
Email: paul.knochel
cup.uni-muenchen.de
B. Heinz, D. Djukanovic, M. A. Ganiek, B. Martin, B. Schenkel, P. Knochel, Org. Lett., 2020, 22, 493-496.
DOI: 10.1021/acs.orglett.9b04254
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Abstract
A selective acylation of readily accessible organomagnesium reagents with commercially available esters proceeds in short residence times in continuous flow. Flow conditions prevent premature collapse of the hemiacetal intermediates despite noncryogenic conditions, thus furnishing ketones in good yields.
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Key Words
Acylation, Trifluoromethyl Ketones, Grignard Reaction, Flow Chemistry
ID: J54-Y2020
