Highly Enantioselective Nickel-Catalyzed Hydrocyanation of Disubstituted Methylenecyclopropanes Enabled by TADDOL-based Diphosphite Ligands
Rongrong Yu and Xianjie Fang*
*School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, People’s Republic of China,
Email: fangxj
sjtu.edu.cn
R. Yu, X. Fang, Org. Lett., 2020, 22, 493-496.
DOI: 10.1021/acs.orglett.9b04374
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Abstract
TADDOL-based diphosphite ligands were applied in the nickel-catalyzed asymmetric hydrocyanation of disubstituted methylenecyclopropanes to provide allylic nitriles in good yield with excellent enantioselectivities.
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Nickel-Catalyzed Asymmetric Hydrocyanation of Allenes
J. Long, J. Gao, X. Fang, Org. Lett., 2020, 22, 376-380.
Key Words
ID: J54-Y2020
