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Highly Enantioselective Nickel-Catalyzed Hydrocyanation of Disubstituted Methylenecyclopropanes Enabled by TADDOL-based Diphosphite Ligands

Rongrong Yu and Xianjie Fang*

*School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, People’s Republic of China, Email:

R. Yu, X. Fang, Org. Lett., 2020, 22, 493-496.

DOI: 10.1021/acs.orglett.9b04374

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TADDOL-based diphosphite ligands were applied in the nickel-catalyzed asymmetric hydrocyanation of disubstituted methylenecyclopropanes to provide allylic nitriles in good yield with excellent enantioselectivities.

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Nickel-Catalyzed Asymmetric Hydrocyanation of Allenes

J. Long, J. Gao, X. Fang, Org. Lett., 2020, 22, 376-380.

Key Words


ID: J54-Y2020