Visible-Light-Induced Deoxygenation/Defluorination Protocol for Synthesis of γ,γ-Difluoroallylic Ketones
Yuan-Qiang Guo, Ruiguo Wang, Hongjian Song, Yuxiu Liu and Qingmin Wang*
*Research Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, People's Republic of China,
Email: wangqm
nankai.edu.cn
Y.-Q. Guo, R. Wang, H. Song, Y. Liu, Q. Wang, Org. Lett., 2020, 22, 709-713.
DOI: 10.1021/acs.orglett.9b04504
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Abstract
An efficient, practical photocatalytic deoxygenation/defluorination protocol provides γ,γ-difluoroallylic ketones from commercially available aromatic carboxylic acids and α-trifluoromethyl alkenes in the presence of triphenylphosphine. The protocol offers good functional group tolerance and a broad substrate scope.
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Key Words
difluoroalkenes, allylation, triphenylphosphine, photochemistry
ID: J54-Y2020
