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Visible-Light-Induced Deoxygenation/Defluorination Protocol for Synthesis of γ,γ-Difluoroallylic Ketones

Yuan-Qiang Guo, Ruiguo Wang, Hongjian Song, Yuxiu Liu and Qingmin Wang*

*Research Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, People's Republic of China, Email:

Y.-Q. Guo, R. Wang, H. Song, Y. Liu, Q. Wang, Org. Lett., 2020, 22, 709-713.

DOI: 10.1021/acs.orglett.9b04504

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An efficient, practical photocatalytic deoxygenation/defluorination protocol provides γ,γ-difluoroallylic ketones from commercially available aromatic carboxylic acids and α-trifluoromethyl alkenes in the presence of triphenylphosphine. The protocol offers good functional group tolerance and a broad substrate scope.

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Key Words

difluoroalkenes, allylation, triphenylphosphine, photochemistry

ID: J54-Y2020