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Iodine-Mediated Oxidative Cyclization of 2-(Pyridin-2-yl)acetate Derivatives with Alkynes: Condition-Controlled Selective Synthesis of Multisubstituted Indolizines

Lisheng He, Yuzhu Yang*, Xiaolan Liu, Guangyan Liang, Chunyan Li, Daoping Wang, Weidong Pan*

*State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 3491 Baijin Road, Guiyang 550014, P. R. China, Email:,

L. He, Y. Yang, X. Liu, G. Liang, C. Li, D. Wang, W. Pan, Synthesis, 2020, 52, 459-470.

DOI: 10.1055/s-0039-1690229

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An iodine-mediated oxidative cyclization reaction between 2-(pyridin-2-yl)acetate derivatives and different alkynes provides substituted indolizines in a regio- and chemoselective fashion.

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Key Words

indolizines, iodine, radical process, regioselective, chemoselective

ID: J66-Y2020