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Selective Dehydrogenative Acylation of Enamides with Aldehydes Leading to Valuable β-Ketoenamides

Rui-Hua Liu, Zhen-Yao Shen, Cong Wang, Teck-Peng Loh and Xu-Hong Hu*

*Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China, Email:

R.-H. Liu, Z.-Y. Shen, C. Wang, T.-P. Loh, X.-H. Hu, Org. Lett., 2020, 22, 944-949.

DOI: 10.1021/acs.orglett.9b04495

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An earth-abundant iron catalyst enables a dehydrogenative acylation of enamides with aldehydes to provide valuable β-ketoenamides with excellent functional group tolerance. The C-H acylation occurs with absolute Z-selectivity.

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Key Words

enamines, DTBP

ID: J54-Y2020