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Nickel-Catalyzed Deaminative Acylation of Activated Aliphatic Amines with Aromatic Amides via C-N Bond Activation

Chu-Guo Yu and Yutaka Matsuo*

*Department of Chemistry, School of Chemistry and Materials Science, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China, Email: matsuoustc.edu.cn

C.-G. Yu, Y. Matsuo, Org. Lett., 2020, 22, 950-955.

DOI: 10.1021/acs.orglett.9b04497 (free Supporting Information)



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Abstract

A Ni-catalyzed reductive deaminative cross-electrophile coupling reaction between Katritzky salts and aromatic amides provides ketones. Due to mild reaction conditions and high functional group tolerance, this cross-coupling strategy is expected to be useful for late-stage functionalization of complex compounds.

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Key Words

acylation. manganese


ID: J54-Y2020