Nickel-Catalyzed Deaminative Acylation of Activated Aliphatic Amines with Aromatic Amides via C-N Bond Activation
Chu-Guo Yu and Yutaka Matsuo*
*Department of Chemistry, School of Chemistry and Materials Science, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China, Email: matsuoustc.edu.cn
C.-G. Yu, Y. Matsuo, Org. Lett., 2020, 22, 950-955.
DOI: 10.1021/acs.orglett.9b04497 (free Supporting Information)
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A Ni-catalyzed reductive deaminative cross-electrophile coupling reaction between Katritzky salts and aromatic amides provides ketones. Due to mild reaction conditions and high functional group tolerance, this cross-coupling strategy is expected to be useful for late-stage functionalization of complex compounds.
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