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Synthesis of Tertiary Benzylic Nitriles via Nickel-Catalyzed Markovnikov Hydrocyanation of α-Substituted Styrenes

Yidan Xing, Rongrong Yu and Xianjie Fang*

*School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, People’s Republic of China, Email:

Y. Xing, R. Yu, X. Fang, Org. Lett., 2020, 22, 1008-1012.

DOI: 10.1021/acs.orglett.9b04554

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A nickel-catalyzed Markovnikov hydrocyanation of α-substituted styrenes enables the synthesis of tertiary benzylic nitriles in good yields. This Lewis-acid-free transformation features an unprecedented functional groups tolerance.

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Key Words


ID: J54-Y2020