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A Method for the Preparation of β-Amino-α,β-unsaturated Carbonyl Compounds: Study of Solvent Effect and Mechanism

R. S. Reyno, Akash Sugunan, S. Ranganayakulu, Cherumuttathu H. Suresh and Goreti Rajendar*

*School of Chemistry, Indian Institute of Science Education and Research, Thiruvananthapuram, Kerala 695551, India, Email: rajendariisertvm.ac.in

R. S. Reyno, A. Sugunan, S. Ranganayakulu, C. H. Suresh, G. Rajendar, Org. Lett., 2020, 22, 1040-1045.

DOI: 10.1021/acs.orglett.9b04531 (free Supporting Information)


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Abstract

Bench-stable sodium 3-oxo-enolates can be reacted with amines in the presence of an acid and a desiccant to provide β-amino-α,β-unsaturated carbonyl compounds.


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Key Words

enaminones


ID: J54-Y2020