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Transfer Hydrogenation of Ketones and Imines with Methanol under Base-Free Conditions Catalyzed by an Anionic Metal-Ligand Bifunctional Iridium Catalyst

Rongzhou Wang, Xingyou Han, Jing Xu, Peng Liu and Feng Li*

*School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094, People’s Republic of China, Email: fenglinjust.edu.cn

R. Wang, X. Han, J. Xu, P. Liu, F. Li, J. Org. Chem., 2020, 85, 2242-2249.

DOI: 10.1021/acs.joc.9b02957 (free Supporting Information)


Abstract

An anionic iridium complex [Cp*Ir(2,2'-bpyO)(OH)][Na] is a general and highly efficient catalyst for transfer hydrogenation of ketones and imines with methanol as hydrogen source under base-free conditions. Nitro, cyano, and ester groups were tolerated under the reaction conditions.


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Transfer Hydrogenation of Aldehydes and Ketones with Isopropanol under Neutral Conditions Catalyzed by a Metal-Ligand Bifunctional Catalyst [Cp*Ir(2,2′-bpyO)(H2O)]

R. Wang, Y. Tang, M. Xu, C. Meng, F. Li, J. Org. Chem., 2018, 83, 2274-2281.


Key Words

reduction of carbonyl compounds, reduction of imines, methanol


ID: J42-Y2020