Organic Chemistry Portal



tert-Butyl Hydroperoxide-Mediated Oxo-Sulfonylation of 2H-Indazoles with Sulfinic Acid toward Indazol-3(2H)-ones

Payel Ghosh, Susmita Mondal and Alakananda Hajra*

*Department of Chemistry, Visva-Bharati (A Central University), Santiniketan 731235, India, Email:

P. Ghosh, S. Mondal, A. Hajra, Org. Lett., 2020, 22, 1086-1090.

DOI: 10.1021/acs.orglett.9b04617

see article for more reactions


An efficient oxo-sulfonylation protocol enables the synthesis of N-sulfonylated indazolones from 2H-indazoles employing sulfinic acid as a sulfonylating agent in the presence of tert-butyl hydroperoxide (TBHP) under ambient air. A series of structurally diverse 1-sulfonylindazol-3(2H)-one derivatives were obtained in good yields.

see article for more examples

Key Words

indazolones, TBHP, oxygen

ID: J54-Y2020