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A Mechanochemical Zinc-Mediated Barbier-Type Allylation Reaction under Ball-Milling Conditions

JieXiang Yin, Roderick T. Stark, Ian A. Fallis and Duncan L. Browne*

*School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, U.K., Email:

J. Yin, R. T. Stark, I. A. Fallis, D. L. Browne, J. Org. Chem., 2020, 85, 2347-2354.

DOI: 10.1021/acs.joc.9b02876

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A ball-milling-enabled zinc-mediated Barbier-type allylation of a broad range of carbonyl compounds is operationally simple and does not require inert atmospheres or dry solvents. The reaction is applicable across a range of different zinc metal morphologies.

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Key Words

allylation, zinc, mechanochemistry

ID: J42-Y2020