Rhodium-Catalyzed Enantioselective Anti-Markovnikov Hydroformylation of α-Substituted Acryl Acid Derivatives
Shuailong Li, Zhuangxing Li, Cai You, Xiuxiu Li, Jiaxin Yang, Hui Lv* and Xumu Zhang*
*Wuhan University, Wuhan, Hubei 430072; Southern University of Science and Technology, Shenzhen, Guangdong 518000, China, Email: huilvwhu.edu.cn, zhangxmsustc.edu.cn
S. Li, Z. Li, C. You, X. Li, J. Yang, H. Lv, X. Zhang, Org. Lett., 2020, 22, 1108-1112.
DOI: 10.1021/acs.orglett.9b04624 (free Supporting Information)
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A Rh/(S,S)-DTBM-YanPhos complex catalyzes an asymmetric anti-Markovnikov hydroformylation of α-substituted acrylates/acrylamides to provide a series of β-chiral linear aldehydes in high yields and enantioselectivities.
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