Rhodium-Catalyzed Enantioselective Anti-Markovnikov Hydroformylation of α-Substituted Acryl Acid Derivatives

Shuailong Li, Zhuangxing Li, Cai You, Xiuxiu Li, Jiaxin Yang, Hui Lv* and Xumu Zhang*

*Wuhan University, Wuhan, Hubei 430072; Southern University of Science and Technology, Shenzhen, Guangdong 518000, China, Email: huilvwhu.edu.cn, zhangxmsustc.edu.cn

S. Li, Z. Li, C. You, X. Li, J. Yang, H. Lv, X. Zhang, Org. Lett., 2020, 22, 1108-1112.

DOI: 10.1021/acs.orglett.9b04624

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Abstract

A Rh/(S,S)-DTBM-YanPhos complex catalyzes an asymmetric anti-Markovnikov hydroformylation of α-substituted acrylates/acrylamides to provide a series of β-chiral linear aldehydes in high yields and enantioselectivities.

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Key Words

1,4-keto esters, hydroacylation

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ID: J54-Y2020