Electrochemical Oxidative Oxydihalogenation of Alkynes for the Synthesis of α,α-Dihaloketones

Xiangtai Meng, Yu Zhang, Jinyue Luo, Fei Wang, Xiaoji Cao and Shenlin Huang*

*Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, P. R. China, Email: shuangnjfu.edu.cn

X. Meng, Y. Zhang, J. Luo, F. Wang, X. Cao, S. Huang, Org. Lett., 2020, 22, 1169-1174.

DOI: 10.1021/acs.orglett.0c00052

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Abstract

An electrochemical oxydihalogenation of alkynes enables the preparation of α,α-dihaloketones using CHCl₃, CH₂Cl₂, ClCH₂CH₂Cl, and CH₂Br₂ as the halogen source at room temperature.

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Key Words

oxygenation, chlorination, bromination, electrochemistry

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ID: J54-Y2020