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Cobalt-Catalyzed Z to E Isomerization of Alkenes: An Approach to (E)-β-Substituted Styrenes

Hongmei Liu, Man Xu, Cheng Cai, Jianhui Chen*, Yugui Gu and Yuanzhi Xia*

*College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China, Email:,

H. Liu, M. Xu, C. Cai, J. Chen, Y. Gu, Y. Xia, Org. Lett., 2020, 22, 1193-1198.

DOI: 10.1021/acs.orglett.0c00072

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The use of an amido-diphosphine ligand enables an efficient cobalt-catalyzed Z to E isomerization of β-substituted styrenes with good functional tolerance and high stereoselectivity. The reaction could be scaled up to gram-scale with a catalyst loading of 0.1 mol %.

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Key Words


ID: J54-Y2020