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Rhodium-Catalyzed Remote Isomerization of Alkenyl Alcohols to Ketones

Wenke Dong, Hongxuan Yang, Wen Yang* and Wanxiang Zhao*

*College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China, Email: yangwenhnu.edu.cn, zhaowanxianghnu.edu.cn

W. Dong, H. Yang, W. Yang, W. Zhao, Org. Lett., 2020, 22, 1265-1269.

DOI: 10.1021/acs.orglett.9b04508 (free Supporting Information)


Abstract

An efficient remote isomerization of aromatic and aliphatic alkenyl alcohols into ketones is catalyzed by a commercially available catalyst and ligand ([RhCl(cod)]2 and Xantphos). This process features high efficiency, low catalyst loading, good functional group tolerance, and a broad substrate scope.


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Key Words

isomerizations


ID: J54-Y2020