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Homoleptic Bis(trimethylsilyl)amides of Yttrium Complexes Catalyzed Hydroboration Reduction of Amides to Amines

Pengqing Ye, Yinlin Shao*, Xuanzeng Ye, Fangjun Zhang*, Renhao Li, Jiani Sun, Beihang Xu and Jiuxi Chen*

*Wenzhou University, Wenzhou, 325035; Wenzhou Medical University, Wenzhou 325035, P.R. China, Email: shaoylwzu.edu.cn, rjzfjwmu.edu.cn, jiuxichenwzu.edu.cn

P. Ye, Y. Shao, X. Ye, F. Zhang, R. Li, J. Sun, B. Xu, J. Chen, Org. Lett., 2020, 22, 1265-1269.

DOI: 10.1021/acs.orglett.9b04606 (free Supporting Information)


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Abstract

Y[N(TMS)2]3 is an efficient homogeneous catalyst for the hydroboration of secondary amides and tertiary amides to provide the corresponding amines. The reaction tolerates various functional groups such as cyano, nitro, and vinyl groups.

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Key Words

reduction of amides, pinacolborane


ID: J54-Y2020