Organic Chemistry Portal

Abstracts

Search:

Copper-Catalyzed One-Pot Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones from 2-Nitrobenzonitriles and Carbonyl Compounds Mediated by Diboronic Acid in Methanol-Water

Qixing Liu, Yuebo Sui, Yin Zhang, Kaili Zhang, Yongsheng Chen, Haifeng Zhou*

*College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China, Email: zhouhfctgu.edu.cn

Q. Liu, Y. Sui, Y. Zhang, K. Zhang, Y. Chen, H. Zhou, Synlett, 2020, 31, 275-279.

DOI: 10.1055/s-0037-1610740 (free Supporting Information)


Abstract

A copper-catalyzed one-pot reaction of 2-nitrobenzonitriles and various carbonyl compounds in the presence of diboronic acid as a reductant provides 2,3-dihydroquinazolin-4(1H)-ones with good functional-group tolerance in good yields under mild conditions.


see article for more examples



Key Words

copper catalysis, tetrahydroxydiboron, dihydroquinazolinones, carbonyl compounds, nitrobenzonitriles


ID: J72-Y2020