Copper-Catalyzed One-Pot Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones from 2-Nitrobenzonitriles and Carbonyl Compounds Mediated by Diboronic Acid in Methanol-Water
Qixing Liu, Yuebo Sui, Yin Zhang, Kaili Zhang, Yongsheng Chen, Haifeng Zhou*
*College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China, Email: zhouhfctgu.edu.cn
Q. Liu, Y. Sui, Y. Zhang, K. Zhang, Y. Chen, H. Zhou, Synlett, 2020, 31, 275-279.
DOI: 10.1055/s-0037-1610740
Abstract
A copper-catalyzed one-pot reaction of 2-nitrobenzonitriles and various carbonyl compounds in the presence of diboronic acid as a reductant provides 2,3-dihydroquinazolin-4(1H)-ones with good functional-group tolerance in good yields under mild conditions.
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Key Words
copper catalysis, tetrahydroxydiboron, dihydroquinazolinones, carbonyl compounds, nitrobenzonitriles
ID: J72-Y2020