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Kolbe Anodic Decarboxylation as a Green Way To Access 2-Pyrrolidinones

Mathilde Quertenmont, Iain Goodall, Kevin Lam*, István Markó and Olivier Riant*

*University of Greenwich, Chatham Maritime ME4 4TB, UK; Université Catholique de Louvain (UCL), 1348 Louvain-la-Neuve, Belgium, Email:,

M. Quertenmont, I. Goodall, K. Lam, I. Markó, O. Riant, Q. Wan, Org. Lett., 2020, 22, 1771-1775.

DOI: 10.1021/acs.orglett.0c00056

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Electrosynthesis enables an effective and environmentally friendly pyrrolidinone synthesis via Kolbe decarboxylation, followed by an intramolecular radical cyclization and a radical-radical cross-coupling.

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Key Words

γ-lactams, Kolbe Electrolysis, electrochemistry

ID: J54-Y2020