Sequential C-S and S-N Coupling Approach to Sulfonamides
Kai Chen, Wei Chen, Bing Han, Wanzhi Chen*, Miaochang Liu and Huayue Wu*
*Zhejiang University, 38 Zheda Road, Hangzhou 310027; Wenzhou University, Wenzhou 325027, China, Email: chenwzzzju.edu.cn, huayuewuwzu.edu.cn
K. Chen, W. Chen, B. Han, W. Chen, M. Liu, H. Wu, Org. Lett., 2020, 22, 1841-1845.
DOI: 10.1021/acs.orglett.0c00183
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Abstract
A one-pot three-component reaction involving nitroarenes, (hetero)arylboronic acids, and potassium pyrosulfite provides a broad range of sulfonamides bearing different reactive functional groups in very good yields through sequential C-S and S-N coupling.
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Key Words
sulfonamides (S-N coupling, C-S coupling), multicomponent reactions
ID: J54-Y2020