Organic Chemistry Portal

Abstracts

Search:

Sequential C-S and S-N Coupling Approach to Sulfonamides

Kai Chen, Wei Chen, Bing Han, Wanzhi Chen*, Miaochang Liu and Huayue Wu*

*Zhejiang University, 38 Zheda Road, Hangzhou 310027; Wenzhou University, Wenzhou 325027, China, Email: chenwzzzju.edu.cn, huayuewuwzu.edu.cn

K. Chen, W. Chen, B. Han, W. Chen, M. Liu, H. Wu, Org. Lett., 2020, 22, 1841-1845.

DOI: 10.1021/acs.orglett.0c00183



see article for more reactions

Abstract

A one-pot three-component reaction involving nitroarenes, (hetero)arylboronic acids, and potassium pyrosulfite provides a broad range of sulfonamides bearing different reactive functional groups in very good yields through sequential C-S and S-N coupling.


see article for more examples



Key Words

sulfonamides (S-N coupling, C-S coupling), multicomponent reactions


ID: J54-Y2020