Catalytic Acceptorless Dehydrogenation of Aliphatic Alcohols

Hiromu Fuse, Harunobu Mitsunuma* and Motomu Kanai*

*Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan, Email: h-mitsunumamol.f.u-tokyo.ac.jp, kanaimol.f.u-tokyo.ac.jp

H. Fuse, H. Mitsunuma, M. Kanai, J. Am. Chem. Soc., 2020, 142, 4493-4499.

DOI: 10.1021/jacs.0c00123

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Abstract

A ternary hybrid catalyst system comprising a photoredox catalyst, a thiophosphate organocatalyst, and a nickel catalyst enables an acceptorless dehydrogenation of aliphatic secondary alcohols to ketones under visible light irradiation at room temperature in high yield without producing side products (except H₂ gas).

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Key Words

oxidation of alcohols, photochemistry

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ID: J48-Y2020