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A Copper(I)-Mediated Tandem Three-Component Synthesis of 5-Allyl-1,2,3-triazoles

Yoona Song, Soyun Lee, Palash Dutta, Jae-Sang Ryu*

*College of Pharmacy & Graduate School of Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-Gu, Seoul 03760, Republic of Korea, Email: ryujewha.ac.kr

Y. Song, S. Lee, P. Dutta, J.-S. Ryu, Synthesis, 2020, 52, 744-754.

DOI: 10.1055/s-0039-1691506 (free Supporting Information)


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Abstract

A copper(I)-mediated tandem three-component reaction using alkynes, azides, allyl iodides, CuI and NaNH2 provides 5-allyl-1,2,3-triazoles smoothly at room temperature in good yields. The products can be further converted into 1,2,3-triazole-fused tricyclic scaffolds.

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Key Words

1,2,3-triazoles, multicomponent reactions, one-pot reactions, click chemistry, copper catalyst


ID: J66-Y2020