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Electrochemical Oxidative Intramolecular N-S Bond Formation: Synthesis of 3-Substituted 5-Amino-1,2,4-Thiadiazoles

Zan Yang, Jiaqi Zhang, Liping Hu, Lijun Li, Kun Liu*, Tao Yang* and Congshan Zhou*

*College of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang 414006, China, Email:,,

Z. Yang, J. Zhang, L. Hu, L. Li, K. Liu, T. Yang, C. Zhou, J. Org. Chem., 2020, 85, 3358-3363.

DOI: 10.1021/acs.joc.9b03155


An electro-oxidative intramolecular dehydrogenative N-S bond formation of imidoyl thioureas provides a broad range of 3-substituted 5-amino-1,2,4-thiadiazoles derivatives in good to excellent yields with excellent functional group tolerance under catalyst- and oxidant-free conditions at room temperature.

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Key Words

1,2,4-thiadiazoles, electrochemistry

ID: J42-Y2020