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An Efficient Palladium-Catalysed Aminocarbonylation of Benzyl Chlorides

Eloise Rilvin-Derrick, Niall Oram, Jeffery Richardson*

*Discovery Research and Technologies, Eli Lilly and Company, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey, GU20 6PH, UK, Email:

E. Rilvin-Derrick, N. Oram, J. Richardson, Synlett, 2020, 31, 369-372.

DOI: 10.1055/s-0039-1690786

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An improved procedure for the aminocarbonylation of benzyl chloride derivatives provides 2-arylacetamides under mild conditions using an inexpensive phosphine ligand, carbon monoxide and either primary or secondary amines.

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Key Words

palladium catalysis, aminocarbonylation, amides, reaction optimisation, multicomponent reactions

ID: J72-Y2020