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Copper-Catalyzed Decarboxylative Cycloaddition of Propiolic Acids, Azides, and Arylboronic Acids: Construction of Fully Substituted 1,2,3-Triazoles

Xiang-Xiang Wang, Yangchun Xin, Yi Li, Wen-Jin Xia, Bin Zhou, Rui-Rong Ye and Ya-Min Li*

*Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, P. R. China, Email:

X.-X. Wang, Y. Xin, Y. Li, W.-J. Xia, B. Zhou, R.-R. Ye, Y.-M. Li, J. Org. Chem., 2020, 85, 3576-3586.

DOI: 10.1021/acs.joc.9b03285

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An efficient and convenient, copper-catalyzed decarboxylative cycloaddition of propiolic acids, azides, and arylboronic acids provides fully substituted 1,2,3-triazoles from readily available starting materials. A possible mechanism is proposed.

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proposed mechanism

Key Words

1,2,3-triazoles, multicomponent reactions, oxygen

ID: J42-Y2020