Iron-Catalyzed Reductive Vinylation of Tertiary Alkyl Oxalates with Activated Vinyl Halides
Yang Ye, Haifeng Chen, Ken Yao and Hegui Gong*
*School of Materials Science and Engineering, Center for Supramolecular Chemistry and Catalysis and Department of Chemistry, Shanghai University, Shanghai, China,
Email: hegui_gong
shu.edu.cn
Y. Ye, H. Chen, K. Yao, H. Gong, Org. Lett., 2020, 22, 2070-2075.
DOI: 10.1021/acs.orglett.0c00561
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Abstract
An efficient Fe-catalyzed cross-electrophile coupling of vinyl halides with tertiary alkyl methyl oxalates provides vinylated carbon quaternary centers with excellent functional group tolerance and broad substrate scope. A cascade radical cyclization and vinylation affords complex bicyclic and spiral structural motifs.
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Key Words
ID: J54-Y2020
