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Transition-Metal-Free Approach to Polysubstituted Furans

Changming You, Zhenming Zhang, Yongliang Tu, Hong Tang, Yuanfeng Wang, Da Long and Junfeng Zhao*

*College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, People’s Republic of China, Email: zhaojfjxnu.edu.cn

C. You, Z. Zhang, Y. Tu, H. Tang, Y. Wang, D. Long, J. Zhao, J. Org. Chem., 2020, 85, 3902-3910.

DOI: 10.1021/acs.joc.9b03006 (free Supporting Information)



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Abstract

A convenient and straightforward synthesis of 2,3-disubstituted and 2,3,5-trisubstituted furans proceeds via a base-promoted domino reaction of β-keto compounds with vinyl dichlorides under operationally simple reaction conditions. The reaction features easily available starting materials, a broad substrate scope, and good functional group tolerance.

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Key Words

furans


ID: J42-Y2020