Electrochemical Synthesis of α-Ketoamides under Catalyst-, Oxidant-, and Electrolyte-Free Conditions
Jin-Yang Chen, Hong-Yu Wu, Qing-Wen Gui, Xiao-Ran Han, Yan Wu, Kui Du, Zhong Cao, Ying-Wu Lin and Wei-Min He*
*Changsha University of Science and Technology, Changsha 410114, China, Email: weiminhe2016
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J.-Y. Chen, H.-Y. Wu, Q.-W. Gui, X.-R. Han, Y. Wu, K. Du, Z. Cao, Y.-W. Lin, W.-M. He, Org. Lett., 2020, 22, 2206-2209.
DOI: 10.1021/acs.orglett.0c00387
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Abstract
A direct electrochemical amidation of α-ketoaldehydes and amines without electrolytes at ambient temperature enables a catalyst- and oxidant-free preparation of α-ketoamides with hydrogen as the sole byproduct. The reaction offers clean and mild conditions, excellent functional-group tolerance, and high atom economy and scalability.
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Key Words
oxidative amidation, electrochemistry
ID: J54-Y2020
