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Electrochemical Synthesis of α-Ketoamides under Catalyst-, Oxidant-, and Electrolyte-Free Conditions

Jin-Yang Chen, Hong-Yu Wu, Qing-Wen Gui, Xiao-Ran Han, Yan Wu, Kui Du, Zhong Cao, Ying-Wu Lin and Wei-Min He*

*Changsha University of Science and Technology, Changsha 410114, China, Email:

J.-Y. Chen, H.-Y. Wu, Q.-W. Gui, X.-R. Han, Y. Wu, K. Du, Z. Cao, Y.-W. Lin, W.-M. He, Org. Lett., 2020, 22, 2206-2209.

DOI: 10.1021/acs.orglett.0c00387

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A direct electrochemical amidation of α-ketoaldehydes and amines without electrolytes at ambient temperature enables a catalyst- and oxidant-free preparation of α-ketoamides with hydrogen as the sole byproduct. The reaction offers clean and mild conditions, excellent functional-group tolerance, and high atom economy and scalability.

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Key Words

oxidative amidation, electrochemistry

ID: J54-Y2020