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Directing-Group-Enabled Cycloaddition of Azides and Alkynes toward Functionalized Triazoles

Linwei Zeng, Zhencheng Lai, Chen Zhang, Hujun Xie and Sunliang Cui*

*College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China, Email:

L. Zeng, Z. Lai, C. Zhang, H. Xie, S. Cui, Org. Lett., 2020, 22, 2220-2224.

DOI: 10.1021/acs.orglett.0c00394

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A directing-group-enabled regioselective Ir-catalyzed (3+2) cycloaddition of azides and alkynes provides functionalized triazoles under mild conditions. The triazene directing group can be replaced by diverse groups, including amino, amide, halogen, and heterocycle substituents.

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Key Words

1,2,3-triazoles, nickel

ID: J54-Y2020