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A General C(sp3)-C(sp3) Cross-Coupling of Benzyl Sulfonylhydrazones with Alkyl Boronic Acids

Rohan R. Merchant* and Jovan A. Lopez

*Department of Discovery Chemistry, Merck & Co., Inc., South San Francisco, California 94080, United States, Email:

R. R. Merchant, J. A. Lopez, Org. Lett., 2020, 22, 2271-2275.

DOI: 10.1021/acs.orglett.0c00471

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Cs2CO3 promotes a general transition-metal-free cross-coupling between benzylic sulfonylhydrazones and alkyl boronic acids. The reaction is operationally simple and exhibits a broad substrate scope.

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Key Words

Benzylation, Cyclopentanes, Alkyl Boronic Acids

ID: J54-Y2020