A General C(sp³)-C(sp³) Cross-Coupling of Benzyl Sulfonylhydrazones with Alkyl Boronic Acids

Rohan R. Merchant* and Jovan A. Lopez

*Department of Discovery Chemistry, Merck & Co., Inc., South San Francisco, California 94080, United States, Email: rohan.merchantmerck.com

R. R. Merchant, J. A. Lopez, Org. Lett., 2020, 22, 2271-2275.

DOI: 10.1021/acs.orglett.0c00471

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Abstract

Cs₂CO₃ promotes a general transition-metal-free cross-coupling between benzylic sulfonylhydrazones and alkyl boronic acids. The reaction is operationally simple and exhibits a broad substrate scope.

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Key Words

Benzylation, Cyclopentanes, Alkyl Boronic Acids

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ID: J54-Y2020