Electrochemical Synthesis of Carbodiimides via Metal/Oxidant-Free Oxidative Cross-Coupling of Amines and Isocyanides

Bhanwar Kumar Malviya, Pradeep K. Jaiswal, Ved Prakash Verma, Satpal Singh Badsara and Siddharth Sharma*

*Department of Chemistry, Mohanlal Sukhadia University, Udaipur, 313001, India, Email: siddharthmlsu.ac.in

B. K. Malviya, P. K. Jaiswal, V. P. Verma, S. S. Badsara, S. Sharma, Org. Lett., 2020, 22, 2323-2327.

DOI: 10.1021/acs.orglett.0c00510

---

see article for more reactions

Abstract

An electrochemical oxidative cross-coupling of amines with aryl and aliphatic isocyanides proceeds without involving any transition-metal catalyst, oxidant, or toxic reagents in an undivided cell to provide carbodiimides in good yields with H₂ as the only byproduct. A subsequent optional hydrolysis provides ureas in situ.

see article for more examples

---

---

Key Words

carbodiimides, electrochemistry, isocyanides

---

ID: J54-Y2020