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Synthesis of 2-Imidazolines via Palladium-Catalyzed Cyclization Reaction of 2,3-Allenyl Amines and Aryl Iodides

Yue Liu, Cheng Zhang, Xiaoxia Liang, Xianzhong Zeng, Rongmei Lu, Zixuan Fang, Shaoyu Wang, Yanjun Liu, Jinxing Hu*

*School of Pharmacy, Weifang Medical University, Weifang, 261053, P. R. of China, Email: jinxinghu2013wfmc.edu.cn

Y. Liu, C. Zhang, X. Liang, X. Zeng, R. Lu, Z. Fang, S. Wang, Y. Liu, J. Hu, Synthesis, 2020, 52, 901-908.

DOI: 10.1055/s-0037-1610742


Abstract

A palladium-catalyzed cyclization of 2,3-allenyl amines with aryl iodides provides polysubstituted 2-imidazoline derivatives in good yields via formation of new carbon-carbon and carbon-nitrogen bonds in a single synthetic operation.


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Key Words

2-imidazolines, allenes, amines, cyclization, imidazoline, palladium


ID: J66-Y2020