Palladium-Catalyzed Decarbonylative Alkylation of Acyl Fluorides

Liyan Fu, Qiang Chen, Zhenhua Wang and Yasushi Nishihara*

*Research Institute for Interdisciplinary Science, Okayama University, 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530, Japan, Email: ynishihaokayama-u.ac.jp

L. Fu, Q. Chen, Z. Wang, Y. Nishihara, Org. Lett., 2020, 22, 2350-2353.

DOI: 10.1021/acs.orglett.0c00542

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Abstract

Palladium-catalyzed decarbonylative alkylation reactions of acyl fluorides with alkylboranes having β-hydrogens enable (sp²)-C(sp³) bond formation via a highly efficient decarbonylative process. A wide range of functional groups were well tolerated, even at the high temperature required for decarbonylation.

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Key Words

alkylation

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ID: J54-Y2020