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Highly Active and Robust Ruthenium Complexes Based on Hemilability of Hybrid Ligands for C-H Oxidation

Chun-Bo Bo, Qingqing Bu, Xue Li, Ge Ma, Donghui Wei*, Cheng Guo*, Bin Dai and Ning Liu*

*Zhengzhou University, Zhengzhou, Henan 450001; Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009; Shihezi University, Shihezi, Xinjiang 832003, PRC, Email:,,

C.-B. Bo, Q. Bu, X. Li, G. Ma, D. Wei, C. Guo, B. Dai, N. Liu, J. Org. Chem., 2020, 85, 4324-4334.

DOI: 10.1021/acs.joc.0c00025


Ru complexes with tridentate hybrid ligands showed a very strong catalytic activity in water at room temperature for benzylic C-H oxidation. Whereas NHCs with a stronger donor ability stabilize the Ru center; nitrogen ligands with a relatively weaker donor ability release from the Ru center, so that they induce a reaction.

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Key Words

benzylic oxidation, TBHP

ID: J42-Y2020