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Iodobenzene-Catalyzed Oxidative Cyclization for the Synthesis of Highly Functionalized Cyclopropanes

Yang Li, Hao Guo, Renhua Fan*

*Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai 200438, P. R. of China, Email:

Y. Li, H. Guo, R. Fan, Synthesis, 2020, 52, 928-932.

DOI: 10.1055/s-0039-1690809

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Iodobenzene catalyzes an oxidative cyclization of Michael adducts of activated methylene compounds with nitroolefins or chalcones in the presence of mCPBA as terminal oxidant together with Bu4NI to provide a range of highly functionalized cyclopropanes with high diastereoselectivities.

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Key Words

cyclopropanes, MCPBA, organocatalysis

ID: J66-Y2020