Selective Oxidative Cleavage of 3-Methylindoles with Primary Amines Affording Quinazolinones
Junhui He, Jianyu Dong, Lebin Su, Shaofeng Wu, Lixin Liu, Shuang-Feng Yin and Yongbo Zhou*
*State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Email: zhouybhnu.edu.cn
J. He, J. Dong, L. Su, S. Wu, L. Liu, S.-F. Yin, Y. Zhou, Org. Lett., 2020, 22, 2522-2526.
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An n-Bu4NI-catalyzed reaction of 3-methylindoles with primary amines using TBHP as the unique oxidant provides broad range of quinazolinones in very good yields. The reaction involves oxygenation, nitrogenation, ring-opening, and recyclization.
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