Highly Enantioselective Cobalt-Catalyzed Hydroboration of Diaryl Ketones
Wenbo Liu, Jun Guo, Shipei Xing and Zhan Lu*
*Department of Chemistry, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China, Email: luzhanzju.edu.cn
W. Liu, J. Guo, S. Xing, Z. Lu, Org. Lett., 2020, 22, 2532-2536.
DOI: 10.1021/acs.orglett.0c00293 (free Supporting Information)
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A chiral imidazole iminopyridine as a ligand enables a highly enantioselective cobalt-catalyzed hydroboration of diaryl ketones with pinacolborane to provide chiral benzhydrols in very good yields and ee. This protocol could be carried out in a gram scale under mild reaction conditions with good functional group tolerance.
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J. Chen, C. Chen, C. Ji, Z. Lu, Org. Lett., 2016, 18, 1594-1597.