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Highly Enantioselective Cobalt-Catalyzed Hydroboration of Diaryl Ketones

Wenbo Liu, Jun Guo, Shipei Xing and Zhan Lu*

*Department of Chemistry, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China, Email: luzhanzju.edu.cn

W. Liu, J. Guo, S. Xing, Z. Lu, Org. Lett., 2020, 22, 2532-2536.

DOI: 10.1021/acs.orglett.0c00293 (free Supporting Information)



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Abstract

A chiral imidazole iminopyridine as a ligand enables a highly enantioselective cobalt-catalyzed hydroboration of diaryl ketones with pinacolborane to provide chiral benzhydrols in very good yields and ee. This protocol could be carried out in a gram scale under mild reaction conditions with good functional group tolerance.

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Cobalt-Catalyzed Asymmetric Hydrogenation of 1,1-Diarylethenes

J. Chen, C. Chen, C. Ji, Z. Lu, Org. Lett., 2016, 18, 1594-1597.


Key Words

reduction of ketones, pinacolborane


ID: J54-Y2020