Highly Enantioselective Cobalt-Catalyzed Hydroboration of Diaryl Ketones
Wenbo Liu, Jun Guo, Shipei Xing and Zhan Lu*
*Department of Chemistry, Zhejiang University, 866 Yuhangtang
Road, Hangzhou 310058, China, Email: luzhan
zju.edu.cn
W. Liu, J. Guo, S. Xing, Z. Lu, Org. Lett., 2020, 22, 2532-2536.
DOI: 10.1021/acs.orglett.0c00293
see article for more reactions
Abstract
A chiral imidazole iminopyridine as a ligand enables a highly enantioselective cobalt-catalyzed hydroboration of diaryl ketones with pinacolborane to provide chiral benzhydrols in very good yields and ee. This protocol could be carried out in a gram scale under mild reaction conditions with good functional group tolerance.
see article for more examples
Cobalt-Catalyzed Asymmetric Hydrogenation of 1,1-Diarylethenes
J. Chen, C. Chen, C. Ji, Z. Lu, Org. Lett., 2016, 18, 1594-1597.
Key Words
reduction of ketones, pinacolborane
ID: J54-Y2020
