Rh-Catalyzed C-H Amination/Annulation of Acrylic Acids and Anthranils by Using -COOH as a Deciduous Directing Group: An Access to Diverse Quinolines
Yang Gao*, Jianhong Nie, Yibiao Li, Xianwei Li, Qian Chen, Yanping Huo and Xiao-Qiang Hu*
*Guangdong University of Technology, Guangzhou 510006; South-Central University for Nationalities, Wuhan 430074, China, Email: gaoyanggdut.edu.cn, huxiaoqiangmail.scuec.edu.cn
Y. Gao, J. Nie, Y. Li, X. Li, Q. Chen, Y. Huo, X.-Q. Hu, Org. Lett., 2020, 22, 2600-2605.
DOI: 10.1021/acs.orglett.0c00539 (free Supporting Information)
see article for more reactions
COOH as a weakly coordinating and traceless directing group is essential for a synthesis of diverse polysubstituted quinolines from readily available acrylic acids and anthranils. Diverse polysubstituted quinolines were obtained under mild reaction conditions with simple H2O and CO2 as byproducts.
see article for more examples