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Rh-Catalyzed C-H Amination/Annulation of Acrylic Acids and Anthranils by Using -COOH as a Deciduous Directing Group: An Access to Diverse Quinolines

Yang Gao*, Jianhong Nie, Yibiao Li, Xianwei Li, Qian Chen, Yanping Huo and Xiao-Qiang Hu*

*Guangdong University of Technology, Guangzhou 510006; South-Central University for Nationalities, Wuhan 430074, China, Email:,

Y. Gao, J. Nie, Y. Li, X. Li, Q. Chen, Y. Huo, X.-Q. Hu, Org. Lett., 2020, 22, 2600-2605.

DOI: 10.1021/acs.orglett.0c00539

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COOH as a weakly coordinating and traceless directing group is essential for a synthesis of diverse polysubstituted quinolines from readily available acrylic acids and anthranils. Diverse polysubstituted quinolines were obtained under mild reaction conditions with simple H2O and CO2 as byproducts.

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ID: J54-Y2020