Iron-Catalyzed Silylation of (Hetero)aryl Chlorides with Et3SiBpin
Jia Jia, Xiaoqin Zeng, Zhengli Liu, Liang Zhao, Chun-Yang He*, Xiao-Fei Li* and Zhang Feng*
*Generic Drug Research Center of Guizhou Province, School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou 563003, P. R. China, Email: hechy2002163.com, lixiaofeizmu.edu.cn, fengzhcqu.edu.cn
J. Jia, X. Zeng, Z. Liu, L. Zhao, C.-Y. He, X.-F. Li, Z. Feng, Org. Lett., 2020, 22, 2816-2821.
DOI: 10.1021/acs.orglett.0c00809 (free Supporting Information)
An iron-catalyzed method for the silylation of (hetero)aromatic chlorides features high efficiency, a broad substrate scope, and excellent functional group compatibility. Moreover, this protocol enables the late-stage silylation of some pharmaceuticals.
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