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Iron-Catalyzed Silylation of (Hetero)aryl Chlorides with Et3SiBpin

Jia Jia, Xiaoqin Zeng, Zhengli Liu, Liang Zhao, Chun-Yang He*, Xiao-Fei Li* and Zhang Feng*

*Generic Drug Research Center of Guizhou Province, School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou 563003, P. R. China, Email:,,

J. Jia, X. Zeng, Z. Liu, L. Zhao, C.-Y. He, X.-F. Li, Z. Feng, Org. Lett., 2020, 22, 2816-2821.

DOI: 10.1021/acs.orglett.0c00809 (free Supporting Information)


An iron-catalyzed method for the silylation of (hetero)aromatic chlorides features high efficiency, a broad substrate scope, and excellent functional group compatibility. Moreover, this protocol enables the late-stage silylation of some pharmaceuticals.

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Key Words

silylation, aryl chlorides

ID: J54-Y2020