A General Method for Photocatalytic Decarboxylative Hydroxylation of Carboxylic Acids
Shah Nawaz Khan, Muhammad Kashif Zaman, Ruining Li and Zhankui Sun*
*Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai 200240, China,
Email: zksun
sjtu.edu.cn
S. N. Khan, M. K. Zaman, R. Li, Z. Sun, J. Org. Chem., 2020, 85, 5019-5026.
see article for more reactions
Abstract
A visible light-induced photocatalysis enables a general and practical decarboxylative hydroxylation of a broad range of carboxylic acids using molecular oxygen as the green oxidant. NaBH4 as additive reduces unstable peroxyl radical intermediates in situ.
see article for more examples
proposed mechanism
Key Words
decarboxylation, hydroxylation, benzylic alcohols, oxygen, photochemistry
ID: J42-Y2020
