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Nickel-Catalyzed Cross-Coupling of Alkyl Carboxylic Acid Derivatives with Pyridinium Salts via C-N Bond Cleavage

Feba Thomas Pulikottil, Ramadevi Pilli, Rohith Valavil Suku and Ramesh Rasappan*

*School of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram, Vithura, Thiruvananthapuram, Kerala 695551, India, Email:

F. T. Pulikottil, R. Pilli, R. V. Suku, R. Rasappan, Org. Lett., 2020, 22, 2833-2837.

DOI: 10.1021/acs.orglett.0c00554

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A convenient electrophile-electrophile cross-coupling of carboxylic acid derivatives and alkylpyridinium salts via C-N bond cleavage provides various functionalized ketones in very good yields. Besides acid chlorides, carboxylic acids were also employed as acylating agents.

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Key Words

acylation, manganese

ID: J54-Y2020