Nickel-Catalyzed Cross-Coupling of Alkyl Carboxylic Acid Derivatives with Pyridinium Salts via C-N Bond Cleavage
Feba Thomas Pulikottil, Ramadevi Pilli, Rohith Valavil Suku and Ramesh Rasappan*
*School of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram, Vithura, Thiruvananthapuram, Kerala 695551, India, Email: rriisertvm.ac.in
F. T. Pulikottil, R. Pilli, R. V. Suku, R. Rasappan, Org. Lett., 2020, 22, 2833-2837.
DOI: 10.1021/acs.orglett.0c00554 (free Supporting Information)
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A convenient electrophile-electrophile cross-coupling of carboxylic acid derivatives and alkylpyridinium salts via C-N bond cleavage provides various functionalized ketones in very good yields. Besides acid chlorides, carboxylic acids were also employed as acylating agents.
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