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Metal-Free Oxidative Esterification of Ketones and Potassium Xanthates: Selective Synthesis of α-Ketoesters and Esters

Xianglin Luo, Runfa He, Qiang Liu, Yanping Gao, Jingqing Li, Xiuwen Chen, Zhongzhi Zhu, Yubing Huang* and Yibiao Li*

*School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong Province 529090, China, Email:,

X. Luo, R. He, Q. Liu, Y. Gao, J. Li, X. Chen, Z. Zhu, Y. Huang, Y. Li, J. Org. Chem., 2020, 85, 5220-5230.

DOI: 10.1021/acs.joc.9b03272

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An efficient iodine-mediated oxidative esterification of acetophenones provides various α-ketoesters and esters in high yields in the presence of potassium xanthates. The potassium xanthate not only promotes oxidative esterification but also provides an alkoxy moiety for the reaction.

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Key Words

α-ketoesters, oxidative esterification, iodine

ID: J42-Y2020