Rhodium(III)-Catalyzed Three-Component 1,2-Diamination of Unactivated Terminal Alkenes
Sumin Lee, Young Jin Jang, Erik J. T. Phipps, Honghui Lei, Tomislav Rovis*
*Department of Chemistry, Columbia University, New York, NY 10027, USA,
Email: tr2504
columbia.edu
S. Lee, Y. J. Jang, E. J. T. Phipps, H. Lei, T. Rovis, Synthesis, 2020, 52, 1247-1252.
DOI: 10.1055/s-0039-1690756
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Abstract
A one-pot diamination of simple unactivated alkenes using an electrophilic nitrene source and amine nucleophiles provides rapid access to 1,2-vicinal diamines from terminal alkenes on good yield and regioselectivity. The transformation proceeds smoothly through a Rh(III)-catalyzed aziridination of alkenes with subsequent ring opening by primary or secondary amines.
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Key Words
diamination, rhodium(III) catalysis, one-pot synthesis, nitrene
ID: J66-Y2020
