Divergent Synthesis of Tunable Cyclopentadienyl Ligands and Their Application in Rh-Catalyzed Enantioselective Synthesis of Isoindolinone

Wen-Jun Cui, Zhi-Jie Wu, Qing Gu and Shu-Li You*

*Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China, Email: slyousioc.ac.cn

W.-J. Cui, Z.-J. Wu, Q. Gu, S.-L. You, J. Am. Chem. Soc., 2020, 142, 7379-7385.

DOI: 10.1021/jacs.0c02813

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Abstract

Electronically tunable cyclopentadienyl ligands enable a unprecedented Rh-catalyzed enantioselective [4+1] annulation reaction of benzamides and alkenes with a broad substrate scope under mild reaction conditions, providing a variety of isoindolinones with excellent regio- and enantioselectivity.

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Key Words

isoindolinones

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ID: J48-Y2020