Microwave-Accelerated N-Acylation of Sulfoximines with Aldehydes under Catalyst-Free Conditions
Kamal K. Rajbongshi, Srinivas Ambala, Thavendran Govender, Hendrik G. Kruger, Per I. Arvidsson*, Tricia Naicker*
*Catalysis and Peptide Research Unit, University of KwaZuluNatal, Durban, 4001, South Africa, Email: per.arvidssonscilifelab.se, naickert1ukzn.ac.za
K. K. Rajbongshi, S. Ambala, T. Govender, H. G. Kruger, P. I. Arvidsson, T. Naicker, Synthesis, 2020, 52, 1279-1286.
An efficient catalyst-free radical cross-coupling reaction between aromatic aldehydes and sulfoximines took place in the presence of N-bromosuccinimide as the radical initiator under microwave irradiation to afford the corresponding acylated sulfoximines in good yields.
see article for more examples
acylation, radical reactions, sulfoximines, N-bromosuccinimide, microwave synthesis