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Microwave-Accelerated N-Acylation of Sulfoximines with Aldehydes under Catalyst-Free Conditions

Kamal K. Rajbongshi, Srinivas Ambala, Thavendran Govender, Hendrik G. Kruger, Per I. Arvidsson*, Tricia Naicker*

*Catalysis and Peptide Research Unit, University of KwaZuluNatal, Durban, 4001, South Africa, Email:,

K. K. Rajbongshi, S. Ambala, T. Govender, H. G. Kruger, P. I. Arvidsson, T. Naicker, Synthesis, 2020, 52, 1279-1286.

DOI: 10.1055/s-0039-1691589


An efficient catalyst-free radical cross-coupling reaction between aromatic aldehydes and sulfoximines took place in the presence of N-bromosuccinimide as the radical initiator under microwave irradiation to afford the corresponding acylated sulfoximines in good yields.

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Key Words

acylation, radical reactions, sulfoximines, N-bromosuccinimide, microwave synthesis

ID: J66-Y2020