N-Methylation and Trideuteromethylation of Amines via Magnesium-Catalyzed Reduction of Cyclic and Linear Carbamates
Marc Magre, Marcin Szewczyk and Magnus Rueping*
*Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany,
Email: magnus.rueping
rwth-aachen.de
M. Magre, M. Szewczyk, M. Rueping, Org. Lett., 2020, 22, 3209-3214.
DOI: 10.1021/acs.orglett.0c00988
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Abstract
A magnesium-catalyzed reduction of linear and cyclic carbamates, including N-Boc protected amines, provides N-methyl amines and amino alcohols which are of significant interest due to their presence in many biologically active molecules. Furthermore, the reduction can be extended to the formation of N-trideuteromethyl labeled amines.
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Key Words
amines, tert-butyl carbamates, pinacolborane
ID: J54-Y2020
